Sarah Hamed Abdelrahim Eisa <br/><br/>
A pharmaceutical study on tramadol hydrochloride topical preparations /  
 دراسة صيدلية علي عقار الترامادول هيدروكلوريد في مستحضرات للاستخدام الظاهري 
Sarah Hamed Abdelrahim Eisa ; Supervised Iman Ibrahim Soliman , Nadia Abdelkader Soliman , Mona Hassan Abouleinien 
 - Cairo :   Sarah Hamed Abdelrahim Eisa ,   2012 
 - 201 P. :   charts ;   25cm 
<br/><br/>Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutics 
<br/><br/> Tramadol hydrochloride is a centrally acting opioid analgesic. After oral administration it is subjected to first pass metabolism with the M1 metabolite having higher affinity to mu opioid receptor than the parent drug and may be the reason for drug abuse liability. Hence this study aims to make preformulation studies, formulate, and evaluate Tramadol HCI into transdermal films  
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<br/><br/><label>Subjects--Index Terms: </label>Abuse Opioid Tramadol hydrochloride