TY - BOOK AU - Sarah Hamed Abdelrahim Eisa AU - Iman Ibrahim Soliman , AU - Mona Hassan Abouleinien , AU - Nadia Abdelkader Soliman , TI - A pharmaceutical study on tramadol hydrochloride topical preparations / PY - 2012/// CY - Cairo : PB - Sarah Hamed Abdelrahim Eisa , KW - Abuse KW - Opioid KW - Tramadol hydrochloride N1 - Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutics; Issued also as CD N2 - Tramadol hydrochloride is a centrally acting opioid analgesic. After oral administration it is subjected to first pass metabolism with the M1 metabolite having higher affinity to mu opioid receptor than the parent drug and may be the reason for drug abuse liability. Hence this study aims to make preformulation studies, formulate, and evaluate Tramadol HCI into transdermal films UR - http://172.23.153.220/th.pdf ER -