TY - GEN AU - Hanan Naeim Hafez Attia Abougomaah AU - Sanaa Abd El baky Kenawy , AU - Yousreya Ali Maklad , TI - Study of Possible Pharmacological Interactions between a Certain Oral Antidiabetic and Some Antiepileptic Drugs in Experimental Animals / PY - 2006/// CY - Cairo : PB - Hanan Naeim Hafez Attia Abougomaah , KW - diphenylhydantoin sodium KW - gabapentin KW - Gliclazide N1 - Thesis (M.Sc.) - Cairo University - Faculty Of Pharmacy - Department Of Pharmacology and Toxicology; Issued also as CD N2 - There is growing awareness of the effects of diabetes mellitus on the central nervous system and susceptibility of some diabetic patients to epilepsy , hence the necessity to administer an antiepileptic drug simultaneously with an oral hypoglycemic agent Drug - drug interactions were investigated using normal and streptozotocin (60 mg / kg , ip) - induced diabetic rats that were treated with gliclazide (10 mg / kg , po) as an oral hypoglycemic agent , phenytoin sodium salt (50 mg / kg , ip) and gabapentin (25 mg / kg , ip) as antiepileptic drugs UR - http://172.23.153.220/th.pdf ER -