Alaa Afif Abdelraouf <br/><br/>
The association between kir6.2 mutation and type 1 diabetes /  
 العلاقة بين التحور الجينى للجين ( كير 2و6 ) والنوع الاول من البول السكرى 
Alaa Afif Abdelraouf ; Supervised Nadida Abdelhamid Gohar , Shereen Abdelghaffar Taha , Nahla Aly Fawzy Fayek 
 - Cairo :   Alaa Afif Abdelraouf ,   2012 
 - 81Leaves :   charts , facsimiles ;   25cm 
<br/><br/>Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Clinical and Chemical Pathology 
<br/><br/> The pancreatic ATP - sensitive potassium ( Katp ) channel is a critical regulator of beta - cell insulin secretion . Heterozygous activating mutations in the KCNJ11 gene , which encodes the Kir 6.2 subunit of the Katp channel , have been found to cause diabetes in the neonatal period or early infancy . This molecular study hypothesized that KCNJ11 mutations could present clinically as type 1 diabetes 
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<br/><br/><label>Subjects--Index Terms: </label>Katp channel kir6.2  Neonatal diabetes