Aya Mohamed Abdelkader Serry   <br/><br/>
One pot synthesis and biological evaluation of novel heterocyclic compounds /  
 التشييد والتقييم البيولوجى لمركبات جديدة غير متجانسة الحلقة 
Aya Mohamed Abdelkader Serry ; Supervised Ashraf H. Abadi 
 - Cairo :   Aya Mohamed Abdelkader Serry ,   2009 
 - 98Leaves :   charts ;   30cm 
<br/><br/>Thesis (M.Sc.) - German University - Faculty of Postgraduate Studies and Scientific Research - Department of Pharmaceutical Chemistry 
<br/><br/> P38Ü mitogen activated protein kinase regulates the expression of inflammatory cytokines suggesting a role in the pathogenesis of diseases such as rheumatoid arthritis as well as cancer progression . Many heterocyclic compouds have been reported to posses p38 MAP kinase inhibitory properties however the main shortcoming for development into clinical candidates were toxicity and unselectivity towards other kinases