TY - BOOK AU - Aya Mohamed Abdelkader Serry AU - Ashraf H. Mostafa Abadi , TI - One pot synthesis and biological evaluation of novel heterocyclic compounds / PY - 2009/// CY - Cairo : PB - Aya Mohamed Abdelkader Serry , N1 - Thesis (M.Sc.) - German University - Faculty of Postgraduate Studies and Scientific Research - Department of Pharmaceutical Chemistry N2 - P38Ü mitogen activated protein kinase regulates the expression of inflammatory cytokines suggesting a role in the pathogenesis of diseases such as rheumatoid arthritis as well as cancer progression . Many heterocyclic compouds have been reported to posses p38 MAP kinase inhibitory properties however the main shortcoming for development into clinical candidates were toxicity and unselectivity towards other kinases UR - http://172.23.153.220/th.pdf ER -