Noha Hazem Mahmoud Ali Atta <br/><br/>
Synthesis and biological evaluation of novel celecoxib analogues and their evaluation as cyclooxygenases and phosphodiesterase 5 inhibitors /  
 التشييد والتقييم البيولوجى من مشبهات السليكوكسيب وتقيمها كمثبطات انزيمات السيكلواوكسيجيناز والفوسفودايستراز5 
Noha Hazem Mahmoud Ali Atta ; Supervised Ashraf H. Abadi 
 - Cairo :   Noha Hazem Mahmoud Ali Atta ,   2011 
 - 82Leaves :   charts , facsimiles ;   30cm 
<br/><br/>Thesis (M.Sc.) - German University - Faculty of Postgraduate studies and scientific Research - Department of Pharmaceutical Chemistry 
<br/><br/> Non-selective cyclooxgenase (COX) inhibitors are effective anti-inflammatory agents . However , side effects such as gastric ulcers and abdominal pain have been reported . Selective cyclooxygenase-2 (COX-2) inhibitors have less gastric side effects but they were reported to increase the susceptibility of systemic hypertension and thromboembolic complication such as myocardial infarction