TY - BOOK AU - Noha Hazem Mahmoud Ali Atta AU - Ashraf H. Abadi , TI - Synthesis and biological evaluation of novel celecoxib analogues and their evaluation as cyclooxygenases and phosphodiesterase 5 inhibitors / PY - 2011/// CY - Cairo : PB - Noha Hazem Mahmoud Ali Atta , N1 - Thesis (M.Sc.) - German University - Faculty of Postgraduate studies and scientific Research - Department of Pharmaceutical Chemistry N2 - Non-selective cyclooxgenase (COX) inhibitors are effective anti-inflammatory agents . However , side effects such as gastric ulcers and abdominal pain have been reported . Selective cyclooxygenase-2 (COX-2) inhibitors have less gastric side effects but they were reported to increase the susceptibility of systemic hypertension and thromboembolic complication such as myocardial infarction UR - http://172.23.153.220/th.pdf ER -