Heba Abdulla Mohamed <br/><br/>
Synthesis of novel heterocyclic compounds and their biological evaluation as phosphodiesterase inhibitors and anticancer agents /  
 تشييد مركبات جديدة غير متجانسة الحلقة و دراسة تأثيراتها الحيوية كمثبطات للإنزيم فوسفودايستريز و كعقاقير مضادة للسرطان 
Heba Abdulla Mohamed ; Supervised Ashraf H. Abadi 
 - Cairo :   Heba Abdulla Mohamed ,   2010 
 - 139 Leaves :   charts ;   30cm 
<br/><br/>Thesis (M.Sc.) - German University - Faculty of Postgraduate Studies and Scientific Research - Department of Pharmaceutical Chemistry 
<br/><br/> Tadalafil is an orally administered drug used to treat male erectile dysfunction (impotence). It is a Ý-carboline derivative that inhibits PDE 5, leading to elevation of cGMP, vascular relaxation in the corpora cavernosa and penile erection during sexual stimulation. Recently, studies have shown that phosphodiesterases including PDE5 are overexpressed in malignant tumors