TY  - BOOK
AU  - Heba Abdulla Mohamed
AU  - Ashraf Mostafa Abadi , 
TI  - Synthesis of novel heterocyclic compounds and their biological evaluation as phosphodiesterase inhibitors and anticancer agents / 
PY  - 2010///
CY  - Cairo : 
PB  - Heba Abdulla Mohamed , 
N1  - Thesis (M.Sc.) - German University - Faculty of Postgraduate Studies and Scientific Research - Department of Pharmaceutical Chemistry
N2  - Tadalafil is an orally administered drug used to treat male erectile dysfunction (impotence). It is a Ý-carboline derivative that inhibits PDE 5, leading to elevation of cGMP, vascular relaxation in the corpora cavernosa and penile erection during sexual stimulation. Recently, studies have shown that phosphodiesterases including PDE5 are overexpressed in malignant tumors
UR  - http://172.23.153.220/th.pdf
ER  -