Shaimaa Awadain Elsharif <br/><br/>
Synthesis of novel diary I heterocycle derivatives and their evaluation as growth inhibitory agents and phosphodiesterase 3 inhibitors /  
 تشييد مشتقات جديدة لثنائى ارايل غير متجانس الحلقة وتقيم قدرتهم كمثبطات النمو ومنع نشاط الفوسفوداى استراز 3  
Shaimaa Awadain Elsharif ; Supervised Ashraf H. Abadi 
 - Cairo :   Shaimaa Awadain Elsharif ,   2010 
 - 90Leaves :   charts , facsimiles ;   30cm 
<br/><br/>Thesis (M.Sc.) - German University - Faculty of Postgraduate Studies and Scientific Research - Department of Pharmaceutical chemistry 
<br/><br/> Milrinone is a cyanopyridone derivative that has been introduced for the treatment of CHF . Its mechanism of action involves inhibition of PDE3 leading to elevation of cAMP increasing the entry of Ca⁺⁺ ions into the cardiac tissues and hence increasing the contractility of the cardiac muscle