TY - BOOK AU - Shaimaa Awadain Elsharif AU - Ashraf H. Abadi , TI - Synthesis of novel diary I heterocycle derivatives and their evaluation as growth inhibitory agents and phosphodiesterase 3 inhibitors / PY - 2010/// CY - Cairo : PB - Shaimaa Awadain Elsharif , N1 - Thesis (M.Sc.) - German University - Faculty of Postgraduate Studies and Scientific Research - Department of Pharmaceutical chemistry N2 - Milrinone is a cyanopyridone derivative that has been introduced for the treatment of CHF . Its mechanism of action involves inhibition of PDE3 leading to elevation of cAMP increasing the entry of Ca⁺⁺ ions into the cardiac tissues and hence increasing the contractility of the cardiac muscle UR - http://172.23.153.220/th.pdf ER -