Yasmine Magdy Mandour <br/><br/>
Evaluating the role of molecular polar surface area on cell permeation :   A multivariate model /  
Yasmine Magdy Mandour ; Supervised Stefan Laufer , Raimund Niess , Thomas Scior 
 - Cairo :   Yasmine Magdy Mandour ,   2010 
 - 142Leaves :   charts , facsimiles ;   30cm 
<br/><br/>Thesis (M.Sc.) - German University - Faculty of Postgraduate Studies and Scientific Research - Department of Pharmaceutical Chemistry 
<br/><br/> Recent drug design strategies consider the pharmacokinetic properties of drug candidates at early stages of drug development prior to any clinical trials . For some years , many in silico ADME screens have been developed . Polar surfce area (PSA) has been a very popular descriptor for the prediction of drug absorption . This descriptor seems to encode an optimal combination of hydrogen bonding features , molecular polarity and solubility properties