TY - BOOK AU - Yasmine Magdy Mandour AU - Raimund Niess , AU - Stefan Laufer , AU - Thomas Scior , TI - Evaluating the role of molecular polar surface area on cell permeation : : A multivariate model / PY - 2010/// CY - Cairo : PB - Yasmine Magdy Mandour , N1 - Thesis (M.Sc.) - German University - Faculty of Postgraduate Studies and Scientific Research - Department of Pharmaceutical Chemistry N2 - Recent drug design strategies consider the pharmacokinetic properties of drug candidates at early stages of drug development prior to any clinical trials . For some years , many in silico ADME screens have been developed . Polar surfce area (PSA) has been a very popular descriptor for the prediction of drug absorption . This descriptor seems to encode an optimal combination of hydrogen bonding features , molecular polarity and solubility properties UR - http://172.23.153.220/th.pdf ER -