Mona Mohamed Kamal <br/><br/>
Effect of P - glycoprotein blockers on the bioavailability of paclitaxel in experimental animals /  
 تاثير مثبطات البى - جليكوبروتين على النشاط الحيوى لعقار الباكليتاكسيل فى حيوانات التجارب 
Mona Mohamed Kamal ; Supervised Mohamed Taki Eldeen Khayyal , Mahmoud Mohamed Merzabani , Abdelmoneim Mahmoud Osman 
 - Cairo :   Mona Mohamed Kamal ,   2006 
 - 85 P. :   ill ;   30cm 
<br/><br/>Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmacology and Toxicology 
<br/><br/> Paclitaxel (Taxol) is an antineoplastic agent used to treat many types of cancer poor oral absorption and consequently poor bioavailability The poor oral bioavailability results mainly from the activity of the P - glycoprotein (P - gp) efflux pump multi - drug Cyclosporine (an immunosuppressive drug) and verapamil (a calcium channel blocker) were used in this study as examples of P - gp efflux pump blockers 
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<br/><br/><label>Subjects--Index Terms: </label>P-glycoprotein Paclitaxel Verapamil