Abdo Abdo Abdellah Mohamed Elfiky <br/><br/>
Exploring the effect of conformational variability on the biophysical identity of HCV NS5B polymerase /  
 إستكشاف تأثير التغير البنائى على الشخصية البيوفيزيائية لبوليماريز فيروس سى الكبدى الوبائى 
Abdo Abdo Abdellah Mohamed Elfiky ; Supervised Wael M. Elshemey , Wissam A. Gawad , Omar S. Desoky 
 - Cairo :   Abdo Abdo Abdellah Mohamed Elfiky ,   2013 
 - 153 Leaves :   charts ;   25cm 
<br/><br/>Thesis (Ph.D.) - Cairo University - Faculty of Science - Department of Biophysics 
<br/><br/> PS-7977, IDX-84 and R728 are hepatitis C virus (HCV) non-structural 5b (NS5B) RNA dependent RNA polymerase (RdRp) nucleotide inhibitors (NIs) that are currently in phase  (DX-84 and R7128) and  (PS-7977) clinical trials. The activated form of these Direct Acting aAntiviral (DAA) drugs acts on NS5B RdRp through a coordination bond with the two Mg+²  present at the active site of the polymerase 
<br/><br/>
<br/><br/><label>Subjects--Index Terms: </label>HCV Molecular NS5B