TY - BOOK AU - Mennat Allah Ahmed Hammam Bedair AU - Ashraf H. Abadi , TI - Modulating the activity of pyrazoline and pyrazole analogues of celecoxib between phosphodiesterase 5 and cyclooxygenase inhibition / PY - 2012/// CY - Cairo : PB - Mennat Allah Ahmed Hammam Bedair , N1 - Thesis (M.Sc.) - German University - Faculty of Postgraduate Studies and Scientific Research - Department of Pharmaceutical Chemistry N2 - Non steroidal anti - inflammatory drugs are among the most widely prescribed drugs all over the world due to their anti - inflammatory, antipyretic and analgesic effects. However, their use has been associated with serious gastromtestinal side effects that were found to be reduced upon the use of selective COX - 2 inhibitors which are collectively called coxibs UR - http://172.23.153.220/th.pdf ER -