Noura Mohamed Salah Eldin Riad <br/><br/>
Novel melatonergic ligands with potential MT₁⁻ selectivity :   Synthesis and pharmacological evaluation /  
Noura Mohamed Salah Eldin Riad ; Supervised Darius P. Zlotos 
 - Cairo :   Noura Mohamed Salah Eldin Riad ,   2013 
 - 140 Leaves ;   30cm 
<br/><br/>Thesis (M.Sc.) - German University - Faculty of Postgraduate Studies and Scientific Research - Department of Pharmaceutical Chemistry 
<br/><br/> Numerous functions of the neurohormone melatonin are mediated through activation of the G - protein - coupled receptors MT₁⁻ and MT₂. Elucidation of the pathophysiological function of the MT₁ receptor has been hampered mainly by the limited availability of selective full agonist and full antagonist for this receptor subtype. Design and synthesis of selective MT₁ receptor ligands with higher affinity and selectivity may contribute to better understanding of physiological functions mediated by MT₁ receptors