01309cam a2200181 a 4500003000900000005001700009008004100026040002800067041000800095100003500103245017700138260005400315300002400369502013800393520052700531700003601058856003301094EG-GiCUC20250223031030.0140825s2013    ua     f m    000 0 eng d  aEG-GiCUCbengcEG-GiCUC0 aeng0 aNoura Mohamed Salah Eldin Riad10aNovel melatonergic ligands with potential MT₁⁻ selectivity : bSynthesis and pharmacological evaluation / cNoura Mohamed Salah Eldin Riad ; Supervised Darius P. Zlotos  aCairo : bNoura Mohamed Salah Eldin Riad , c2013  a140 Leaves ; c30cm  aThesis (M.Sc.) - German University - Faculty of Postgraduate Studies and Scientific Research - Department of Pharmaceutical Chemistry  aNumerous functions of the neurohormone melatonin are mediated through activation of the G - protein - coupled receptors MT₁⁻ and MT₂. Elucidation of the pathophysiological function of the MT₁ receptor has been hampered mainly by the limited availability of selective full agonist and full antagonist for this receptor subtype. Design and synthesis of selective MT₁ receptor ligands with higher affinity and selectivity may contribute to better understanding of physiological functions mediated by MT₁ receptors0 aDarius P. Zlotos , eSupervisor  uhttp://172.23.153.220/th.pdf