Synthesis and pharmacological evaluation Noura Mohamed Salah Eldin Riad creator Darius P. Zlotos Supervisor text theses ua Cairo Noura Mohamed Salah Eldin Riad 2013 monographic eng

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140 Leaves ; 30cm Numerous functions of the neurohormone melatonin are mediated through activation of the G - protein - coupled receptors MT₁⁻ and MT₂. Elucidation of the pathophysiological function of the MT₁ receptor has been hampered mainly by the limited availability of selective full agonist and full antagonist for this receptor subtype. Design and synthesis of selective MT₁ receptor ligands with higher affinity and selectivity may contribute to better understanding of physiological functions mediated by MT₁ receptors specialized Noura Mohamed Salah Eldin Riad ; Supervised Darius P. Zlotos Thesis (M.Sc.) - German University - Faculty of Postgraduate Studies and Scientific Research - Department of Pharmaceutical Chemistry http://172.23.153.220/th.pdf http://172.23.153.220/th.pdf EG-GiCUC 140825 20250223031030.0 eng