Evaluation of the Correlation between Vitamin D Receptor Polymorphism and the Response to Treatment in Chronic Hepatitis C Patients /
تقييم العلاقة بين تعدد اشكال مستقبلات فيتامين د و الاستجابة للعلاج فى مرضى الالتهاب الكبدى الفيروسى سى
Mai Mohammed Mukhtar ; Supervised Gamal Eldin Esmat , Dina Sabry Abdelfattah , Hany Mofeed Mahmoud Shehab
- Cairo : Mai Mohammed Mukhtar , 2013
- 101 P. : ; 25cm
Thesis (M.Sc.) - Cairo University - Faculty of Medicine- Department of Tropical Medicine
Introduction: Immune effects of vitamin D including its cytokine regulating actions are mediated through the nuclear vitamin D receptor. Genetic polymorphisms affecting the vitamin D receptor FokI gene have been implicated in several immune disorders Aim of the study: In this study we assess the effect of FokI gene polymorphism and vitamin D levels on response to treatment in chronic hepatitis C genotype 4. Patients and methods: Blood samples of 50 responders and 50 non- responders to pegylated interferon and ribavirin were tested for the FokI gene polymorphism and serum vitamin D levels. 20 healthy controls were also tested for serum vitamin D levels