Mona Mohsen Ahmed Abouelghar <br/><br/>
Study of Tumor Necrosis Factor-Related Apoptosis Inducing Ligand (TRAIL) mRNA Expression in Patients with Systemic Lupus Erythematosus/  
 دراسة التعبير للحمض النووي الريبوسومى المرسل لعامل النخر للأورام المرتبط  بمحفز موت الخلايا فى مرضى الذئبة الحمراء 
Mona Mohsen Ahmed Abouelghar ; Supervised Safaa Mostafa Elkaraksy , Noha Mohamed Hosny Shahin , Naglaa Mohamed Kholoussi 
 - Cairo :   Mona Mohsen Ahmed Abouelghar ,   2014 
 - 88 P. :   charts , facsimiles ;   25cm 
<br/><br/>Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Clinical and Chemical Pathology 
<br/><br/> TRAIL (APO-2 ligand) is a transmembrane (type II) glycoprotein which also belongs to the TNF superfamily. TRAIL triggers apoptosis through interaction with the death receptors Death Receptor (DR4) (TRAIL-R1) and (DR5) (TRAIL-R2). There are several indications that TRAIL could be involved in the pathophysiology of autoimmune diseases in general and systemic lupuserythematosus (SLE) in particular. The aim of this study was to investigate TRAIL m RNA expression levels in peripheral blood mononuclear cells(PBMCs) from patients with SLE and to study the association between the results and various clinical and laboratory data of the patients in order to assess the possible role of TRAIL in SLE pathogenesis and its relation to disease activity 
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<br/><br/><label>Subjects--Index Terms: </label>Real time PCR Systemic lupus erythematosus  Tumor necrosis factor related apoptosis inducing ligand