TY  - BOOK
AU  - Doaa Mohamed Hany Abdellatif Hafez 
AU  - Amira Amin Zayed , 
AU  - Khadiga Sayed Sayed , 
AU  - Mona R. E. Abdelhalim , 
TI  - Transforming growth factor beta 1 gene polymorphism  and gene expression of forkhead box p3 in the blood of different cutaneous stages of mycosis f ungoides / 
PY  - 2014///
CY  - Cairo : 
PB  - Doaa Mohamed Hany Abdellatif Hafez , 
KW  - Mycosis fungoides
KW  - Regulatory T cells
KW  - TGF-Ý1 polymorphism
N1  - Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Dermatology and Venerology; Issued also as CD
N2  - Background:. Mycosis fungoides (MF) is the most common type of cutaneous T {u2013}cell lymphomas (CTCLs). Forkhead box P3 (FOXP3) is the specific marker of regulatory T cells (Tregs) and transforming growth factor beta 1 (TGF-Ý1) is their sword cytokine. Studies about involvement of Tregs in MF are controversial. Dysregulation in TGF- Ý1 signaling pathways has been linked to various cancers. Aim of study: To add more insight to the role played by Tregs in MF, by studying the gene expression of FOXP3 and TGF-Ý1 in the blood of MF patients. It also aimed to analyze the relationship between TGF-Ý1gene polymorphism and susceptibility of MF in a sample of Egyptian MF patients. Patients and methods: This case control study included 55 MF patients and 100 controls examined for TGF-Ý1 gene polymorphism  by PCR-RFLP. Gene expression of FOXP3 and TGF- Ý1 in the blood of 25 patients and 25 controls was assessed by real time PCR
UR  - http://172.23.153.220/th.pdf
ER  -