Rasha Refaat Mohammad Aly

Allogeniec peripheral blood stem cell transplantation in patients with severe aplastic anemia, comparing fludarabine based versus anti - thymocyte globuline based conditioning regimens : A retrospective study / زراعة النخاع العظمى من متبرع باستخدام خلايا النخاع الجذعية الطرفية لمرضى فشل النخاع العظمى: مقارنة بين استخدام عقار الفلودارابين و استخدام جلوبيين مضاد الخلايا الثيموسية : دراسة استعادية Rasha Refaat Mohammad Aly ; Supervised Omar Abdelrahman Fahmy , Raafat Mohammad Abdelfattah - Cairo : Rasha Refaat Mohammad Aly , 2014 - 177 P. : charts ; 25cm

Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Internal Medicine

Allogeneic hematopoietic stem cell transplantation (Allo - HSCT) from an HLA matched sibling donor is the initial treatment of choice for newly diagnosed patients with severe aplastic anemia. Regarding the graft type, in 2007 The American society of hematology published data, indicating that BM grafts are preferred to PBPC grafts in young patients undergoing HLA - matched sibling donor transplantation for SAA. The conditioning regimen In order to improve survival in patients older than 30-40 years, the use of less cytotoxic but more immunosuppressive regimens including low - dose cyclo - phosphamide in combination with ATG, while adding fludarabine (Flu), might be an option



Conditioning regimen Fludarabine Severe aplastic anemia