Asmaa Ahmed Elsayed Osman <br/><br/>
Characterization and in vitro differentiation of bone marrow stem cells into hepatocytes /  
 دراسة صفات الخلايا الكبدية المخلقة خارج الجسم من خلايا النخاع الشوكي   
Asmaa Ahmed Elsayed Osman ; Supervised Nesrine Mohamed Elgharbawi , Doaa Atef Soliman , Reham A. Aleem Afefy 
 - Cairo :   Asmaa Ahmed Elsayed Osman ,   2014 
 - 174 P. :   charts , facsimiles ;   25cm 
<br/><br/>Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Clinical and Chemical Pathology 
<br/><br/> Background: Orthotopic liver transplantation is the only definitive therapeutic option available for patients with chronic end-stage liver disease. However, a shortage of suitable donor organs and requirement for immunosuppression restrict its usage, highlighting the need to find suitable alternatives. Stem cell therapy has emerged as a novel approach for the treatment of many human degenerative diseases such as liver cirrhosis. Mesenchymal stem cells (MSC) have the capacity of self-renewal and differentiation into cells of various lineages, MSCs are the most potent component of bone marrow cells in hepatic dif»feren»tiation so they can be isolated from bone marrow (BM) and induced to differentiate into hepatocyte-like cells 
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<br/><br/><label>Subjects--Index Terms: </label>Hepatocyte  In vitro Differentiation Mesenchymal stem cells