TY  - BOOK
AU  - Maged Fathy Abdelzaher Ali 
AU  - Abdelazeim Ali Ahmed Khalaf  , 
AU  - Ashraf Mohamed Hassan Morgan  , 
AU  - Osama Samir Eltawil , 
TI  - In vitro and in vivo studies on aluminum hepatotoxicity in rats / 
PY  - 2014///
CY  - Cairo : 
PB  - Maged Fathy Abdelzaher Ali , 
KW  - Aluminum
KW  - Hepatotoxicity
KW  - Isolated rat hepatocytes
N1  - Thesis (Ph.D.) - Cairo University - Faculty of Veterinary Medicine - Department of Forensic Medicine and Toxicology; Issued also as CD
N2  - Aluminum is a silver-white, malleable, and ductile metal and the third most abundant element in the earth{u2019}s crust, comprising 8.3 percent of its volume. This study concerns with Al hepatoxicity either in vitro or in vivo and the role of DFO and L1as chelating agents to alleviate this effect. Isolated rat hepatocytes were exposed to different concentrations of AlCl (5, 10, 20 æM) to examine AlCl-induced hepatotoxicity. The isolated hepatocytes at the submaximal dose of ALCl were pre-treated with either DFO or L1 to determine their protective effects. Present results indicated that the viability and enzymatic leakage % of LDH, ALT, and AST were significantly affected by AlCl toxicity. Oxidative stress assessed by GSH & TBA-RS levels was also observed. Addition of DFO & L1 to incubated hepatocytes 60 minutes before AlCl exposure resulted in marked ameliorating effect
UR  - http://172.23.153.220/th.pdf
ER  -