Sara Mohammed Abdelwahed <br/><br/>
Assessment of DNA content by flow cytometry and  immunohistochemical expression of BUBR1 in oral epithelial dysplastic Lesions /  
 فى آفات خلل التنسج الطلائى الفمىBUBRIتقييم محتوى الحمض النووى بواسطة التدفق الخلوى وإظهار المناعة الهيستوكيميائية لل  
Sara Mohammed Abdelwahed ; Supervised Naglaa Mohamed Elhossary , Safa Fathy Abdelghani , Abeer Mostafa Elsayed  
 - Cairo :   Sara Mohammed Abdelwahed ,   2014 
 - 115 Leaves :   charts , facsimiles ;   30cm 
<br/><br/>Thesis (Ph.D.) - Cairo University - Faculty of Oral and Dental Medicine  - Department of Oral Pathology 
<br/><br/> Oral epithelial dysplasia represents a relatively late phase in the multistage process of oral carcinogenesis, which is one of the most frequent cancers in the world. Accordingly, our goal was to assess the DNA ploidy status and the immunohistochemical expression of BUBR1 in oral epithelial dysplasia and oral squamous cell carcinoma, correlation of our results with the histopathological findings and evaluation of their diagnostic and prognostic significance. Forty paraffin blocks were investigated and divided into: low and high risk dysplasia, well, moderately and poorly differentiated squamous cell carcinoma. Flow cytometry was used to evaluate the ploidy status, DNA index and S-phase fraction. Immunohistochemical expression of BUBR1 and the area percentage of the positive cells were detected 
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<br/><br/><label>Subjects--Index Terms: </label>DNA ploidy  Oral epithelial dysplasia Oral squamous cell carcinoma