TY - BOOK AU - Sara Mohammed Abdelwahed AU - Abeer Mostafa Elsayed , AU - Naglaa Mohamed Elhossary , AU - Safa Fathy Abdelghani , TI - Assessment of DNA content by flow cytometry and immunohistochemical expression of BUBR1 in oral epithelial dysplastic Lesions / PY - 2014/// CY - Cairo : PB - Sara Mohammed Abdelwahed , KW - DNA ploidy KW - Oral epithelial dysplasia KW - Oral squamous cell carcinoma N1 - Thesis (Ph.D.) - Cairo University - Faculty of Oral and Dental Medicine - Department of Oral Pathology; Issued also as CD N2 - Oral epithelial dysplasia represents a relatively late phase in the multistage process of oral carcinogenesis, which is one of the most frequent cancers in the world. Accordingly, our goal was to assess the DNA ploidy status and the immunohistochemical expression of BUBR1 in oral epithelial dysplasia and oral squamous cell carcinoma, correlation of our results with the histopathological findings and evaluation of their diagnostic and prognostic significance. Forty paraffin blocks were investigated and divided into: low and high risk dysplasia, well, moderately and poorly differentiated squamous cell carcinoma. Flow cytometry was used to evaluate the ploidy status, DNA index and S-phase fraction. Immunohistochemical expression of BUBR1 and the area percentage of the positive cells were detected UR - http://172.23.153.220/th.pdf ER -