TY  - BOOK
AU  - Heba Mohamed Fahmy Abdelbaky
AU  - Anwar Abdelazim Elsayed , 
AU  - Nasr Mahmoud  Radwan , 
AU  - Neveen Amin Noor , 
TI  - Neurobehavioral study on an animal model of multiple sclerosis / 
PY  - 2014///
CY  - Cairo : 
PB  - Heba Mohamed Fahmy Abdelbaky , 
KW  - Demyelination
KW  - Experimental autoimmune encephalomyelitis (EAE)
KW  - Nigella sativa (N.sativa)
N1  - Thesis (Ph.D.) - Cairo University - Faculty of Science - Department of Biophysics; Issued also as CD
N2  - Multiple sclerosis (MS) is an immune mediated, inflammatory  demyelinating neurodegenerative disease of the central nervous system (CNS). Experimental autoimmune encephalomyelitis (EAE) is a well- established animal model of MS. The aim of the present study is to investigate the protective and therapeutic effects of Nigella sativa (N. sativa) seeds (2.8 g / kg body weight) in EAE-induced rats. EAE was induced by single subcutaneous injection in the tail base with 100 æg myelin  oligodendrocyte glycoprotein (MOG) in complete Freund's adjuvant (CFA) containing 1 mg / ml of Mycobacterium tuberculosis. Animals immunized  with MOG were divided into 3 groups: 1- EAE-induced animals (2EAE3 group) received daily oral administration of distilled water until the end of the experiment. 2- The animals of the second group (2N. sativa + EAE3 group) received daily oral administration of N. sativa 2 weeks prior EAE  induction till the end of the experiment. 3- Animals of the third group (2EAE  + N. sativa3 group) received daily oral administration of N. sativa after the  appearance of first clinical signs until the end of the experiment
UR  - http://172.23.153.220/th.pdf
ER  -