TY  - BOOK
AU  - Tamer Hamdy Mahmoud Shosha 
AU  - Fatma Ahmed Elmougy  , 
AU  - Hanaa Mostafa Elkaraksy  , 
AU  - Laila Hussein Mohamed  , 
TI  - Estimation of hepatic fibrosis in Children with chronic liver disease using non invasive serum Biomarkers / 
PY  - 2014///
CY  - Cairo : 
PB  - Tamer Hamdy Mahmoud Shosha  , 
KW  - Chronic liver diseases
KW  - Liver fibrosis
KW  - Non invasive liver biomarkers
N1  - Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Pediatrics; Issued also as CD
N2  - Hyaluronic acid, Ü-2 macroglobulin, apolipoprotein A1 and procollagen III are class I fibrosis biomarkers, derived pathophysiologically from ECM turnover and /or from changes of  fibrogenic cell types particularly hepatic stellate cells and (myo-)  fibroblasts.The aim of this study is to evaluate the non invasive  serum biomarkers; Hyaluronic acid, Ü-2 macroglobulin, Apolipoprotein A1 and Procollagen III, of hepatic fibrosis in children with chronic liver diseases as an alternative to liver biopsy.  In this study the four biomarkers were assessed in 120 patients who attended the Pediatric Hepatology Clinic, New Children Hospital, Cairo University .They all suffered from chronic liver diseases of different etiologies, and the results were correlated with Ishak score  of fibrosis stage. Another 21 healthy children of matched age and sex served as control group. The present study showed significant  increase in hyaluronic acid, apolipoprotien A1, alpha-2 macroglobulin and procollagen III correlating with degree of fibrosis (Ishak Score) in the studied patients compared with controls
UR  - http://172.23.153.220/th.pdf
ER  -