TY  - BOOK
AU  - Mona Mostafa Farid
AU  - Ahmed Talaat Alghoneimy , 
AU  - Azza Abbas Helmy , 
AU  - Hala Mohamed Raslan , 
TI  - Vitamin D and its receptor gene polymorphism in ischemic vascular dementia : : Clinical, laboratory and genetic study / 
PY  - 2015///
CY  - Cairo : 
PB  - Mona Mostafa Farid , 
KW  - Cognition
KW  - Ischemic stroke
KW  - Vitamin D
N1  - Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Neurosurgery; Issued also as CD
N2  - It was observed that vitamin D deficiency and vitamin D receptor gene polymorphism  can influence cognitive performance. Aim: To study the relation between serum vitamin D level, vitamin D receptor gene  polymorphism (Apa-l & Taq-l) and cognitive performance in ischemic stroke without  dementia, ischemic vascular dementia & controls. Results: Vitamin D significantly affects cognitive performance in controls, including,  total score of Addenbrooke's Cognitive Examination Revised (p 0.01), Story A from logical  memory subtest of the Wechsler Memory Scale Revised (p>0.001), Paired Associate  Learning Test (p>0.001) & Paced Auditory Serial Addition Test (p>0.001). PTH affects  cognition in ischemic vascular dementia and controls but not ischemic stroke. Significantly  different Taq-I alleles, (P =0.02) and genotypes (p= 0.009) distribution between studied  groups. Apa-I genotypes polymorphisms were associated with cognitive performance. Conclusion: Vitamin D play an important role in preserving cognitive function of  normal aging but cannot overcome the vascular burden of ischemic stroke or ischemic  vascular dementia. Taq-I polymorphisms hypothesized to be associated with ischemic stroke  and ischemic vascular dementia risks, while Apa-I polymorphisms hypothesized to be  associated with cognitive performance
UR  - http://172.23.153.220/th.pdf
ER  -