Evaluation of the role of keratinocytes apoptosis and impaired cell to cell adhesion in vitiligo: Immunohistochemical expression of MART1, P53 and E-cadherin /
(E-cadherin) و (P53)(MART) تقييم دور موت الخلايا الكيراتينية المبرمج و اضطراب اتصال الخلايا ببعضها في البهاق: التعبير المناعي لكل من
Mohammed Hussien Mostafa Elmahdy ; Supervised Naiema A.M. Marie , Samia Mohammed Gabal , Mostafa Samy Salem
- Cairo : Mohammed Hussien Mostafa Elmahdy , 2015
- 125 P. : charts , facsimiles ; 25cm
Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Pathology
Background: Vitiligo is an acquired, hypomelanotic skin disorder characterized by circumscribed depigmented macules. Most studies on vitiligo have concentrated on the abnormality of melanocytes rather than the abnormality of keratinocytes. Some studies supported the hypothesis that keratinocytes apoptosis and impaired intercellular adhesion may play a role in the pathogenesis of vitiligo. Objectives: To assess the role of keratinocytes apoptosis and impaired intercellular adhesion in the pathogenesis of vitiligo through the studying of immunohistochemical presence and distribution of MART1, P53 and E-cadherin in the epidermis Results: Regarding to immunostaining of both E-cadherin & P53, there was a highly significant difference between lesional biopsies of cases and control groups. Also there was a highly significant difference between lesional biopsies of cases and perilesional and non lesional biopsies of the same cases. No significant difference was noted regarding the disease stability. Conclusion: vitiligo is not a disease confined to melanocytes. Keratinocytes apoptosis and impaired cell to cell adhesion may play prominent role in the pathogenesis of the disease.