02667cam a2200349 a 4500 EG-GiCUC 20250223031405.0 160106s2015 ua dh f m 000 0 eng d EG-GiCUC eng EG-GiCUC eng Deposite M.Sc Cai01.11.27.M.Sc.2015.St.I Stephen Lokudu Loku Lomin Immunohistochemical study of Survivin in some subtypes of breast carcinoma / Stephen Lokudu Loku Lomin ; Supervised Maha Mosaad Mosaad , Mostafa Mohamed Sami Salem , Lubna Omar Elfarouk Abdelsalam دراسة كيميائية نسيجية مناعية لسفافين فى بعض انواع سرطان الثدى Cairo : Stephen Lokudu Loku Lomin , 2015 112 P. : charts , facsimiles ; 25cm Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Pathology Survivin is a cancer gene that is overexpressed in differentiated tissues at high levels in vast majority of tumours. It is novel member of the inhibitor of apoptosis gene family that has been shown to inhibit apoptosis and promote mitosis. Many studies showed aberrant expression of survivin. Clinicopathologic investigations on the role of surviving in breast cancer focusing on its importance as prognostic factors have been limited. In this review, we assessed the expression of survivin in some subtypes of breast cancer. Our retrospective study comprised of 40 specimens of breast cancer. Sample from archived blocks were immunostained for survivin. Survivin expression was evaluated and a weighted score with regards to the intensity and percentage expression of tumour cells were assessed. Survivin expression was detected in 90% of breast carcinomas. The adjacent normal breast tissue was negative for the immunostain. Survivin expression showed significant association with tumour histologic stage, and Her2 status. There was no significant association with age of patients, tumour size, tumour grade, nodal status, estrogen receptor status, and progesterone receptor status. In conclusion, overexpression of Survivin is associated with parameters of poor prognosis in some subtypes of breast carcinoma Issued also as CD Immunohistochemical Parameters Survivin Lubna Omar Elfarouk Abdelsalam , Supervisor Maha Mosaad Mosaad , Supervisor Mostafa Mohamed Sami Salem , Supervisor http://172.23.153.220/th.pdf Enas Cataloger Nazla Revisor ddc TH 54319 54319 ddc 0 CUCL cl210 2024-02-11 Cai01.11.27.M.Sc.2015.St.I 01010110067382000 2023-09-22 00:00:00 TH ddc 0 CUCL cl2u8 2024-02-11 Cai01.11.27.M.Sc.2015.St.I 01020110067382000 2023-09-22 00:00:00 67382.CD CD