Mona Mohamed Mamdouh Abdelfattah Abdelghany creator Gina Assaad Assaad Nakhla Supervisor Maha ElSayed Salama Supervisor Neveen Samir Tahoun Supervisor text theses ua Cairo Mona Mohamed Mamdouh Abdelfattah Abdelghany 2015 monographic eng

print

123 P. : charts , facsimiles ; 25cm Material and methods: Fifty cases of serous effusions were examined on Papanicolaou-stained and Diff quick-stained smears as well as Paraffin-embedded cell blocks. 30 cases were diagnosed as metastatic adenocarcinoma and 20 cases were diagnosed as reactive mesothelial hyperplasia with typical cytomorphologic features. All the cases were studied for E-cadherin and desmin immunoreactivity. Results: The all cases of metastatic adenocarcinoma reacted to E-cadherin and only 3 cases reacted to desmin, whereas among the 20 cases of reactive mesothelial cell hyperplasia, 18 cases stained with desmin and only one case was stained with E-cadherin. Considering the staining of the E-cadherin and desmin under conditions that the cells were stained with E-cadherin but not with desmin, sensitivity=90%, specificity=100%, positive predictive value (PPV)=100%, negative predictive value (NPV)=87% and accuracy=94% to identify metastatic adenocarcinoma. While under conditions that the cells were stained with desmin but not with E-cadherin, sensitivity=85%, specificity=100%, positive predictive value (PPV)=100%, negative predictive value (NPV)=90% and accuracy= 94% to identify reactive mesothelial cell hyperplasia. Conclusion: Employing this short panel can be helpful for better differentiation of adenocarcinoma and reactive mesothelial cells in serous effusions specialized Mona Mohamed Mamdouh Abdelfattah Abdelghany ; Supervised Gina Assaad Assaad Nakhla , Neveen Samir Tahoun , Maha Elsayed Salama Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Pathology Issued also as CD Adenocarcinoma E-cadherin Reactive mesothelial cell http://172.23.153.220/th.pdf http://172.23.153.220/th.pdf EG-GiCUC 160214 20250223031424.0 eng