Passant Essam Eldin Ahmed creator Fahima Mohamed Habib Supervisor Lubna Omar Elfarouk Abdelsalam Supervisor Mohammed Faisal Darweesh Supervisor text theses ua Cairo Passant Essam Eldin Ahmed 2015 monographic eng

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192 P. : charts , facsimiles ; 25cm Breast cancer (BC) is the most common type of cancer among women world wide and leading cause of cancer related deaths. Distant metastases are responsible for the majority of cancer related deaths. Epithelial mesenchymal transition (EMT) is defined by the loss of epithelial characters and acquisition of mesenchymal phenotype. Through EMT, tumor cells acquire fibroblast like properties and exhibit increased motility, helping the escape of tumor cells from the primary tumors and metastasis. Fibronectin (FN) is an extracellular matrix glycoprotein constituting an important part of the tumor associated stroma. It is also considered a mesenchymal marker of EMT. Investigation of immunohistochemical expression of FN by epithelial and stromal cells of female BC and correlation of this expression with the clinico pathological aspects of the tumors. 50 formalin fixed paraffin embedded BC tissue sections were randomly collected. All the available data were collected from the patients{u2019} reports. The paraffin blocks were sectioned, stained with hematoxylin and eosin stains for histologic evaluation. Additional sections were immunostained with FN. Fibronectin expression was studied separately in the tumor cells and tumor stroma specialized Passant Essam Eldin Ahmed ; Supervised Fahima Mohamed Habib , Mohammed Faisal Darweesh , Lubna Omar Elfarouk Abdelsalam Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Pathology Issued also as CD Breast cancer EMT Fibronectin http://172.23.153.220/th.pdf http://172.23.153.220/th.pdf EG-GiCUC 160307 20250223031437.0 eng