02953cam a2200349 a 4500 EG-GiCUC 20250223031439.0 160312s2015 ua f m 000 0 eng d EG-GiCUC eng EG-GiCUC eng Deposite M.Sc Cai01.11.09.M.Sc.2015.Is.P Islam Hassan Mohamed Elsadek Abulnaga Plasminogen activator Inhibitor 1 as a predictor of postoperative atrial fibrillation after cardiopulmonary bypass / Islam Hassan Mohamed Elsadek Abulnaga ; Supervised Suzy Fawzy Michael , Mohamed Fawzy Abdelaleem , Mohamed Ahmed Elbadawy مثبط منشط البلازمينوجين رقم (1) كمتنبئ لحدوث ذبذبة الأذين بعد الجراحة بعد ماكينة القلب و الرئة الصناعى Cairo : Islam Hassan Mohamed Elsadek Abulnaga , 2015 219 P. ; 25cm Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Critical Care Medicine Postoperative AF leads to significant morbidity and prolongation of hospital stay, and complicates 20% to 40% of surgical procedures requiring cardiopulmonarybypass (CPB).⁽¹⁾ This study aims at measuring The efficacy of plasminogen activator Inhibitor-1 (PAI - 1) as a predictor of postoperative atrial fibrillation after cardiopulmonary bypass (CPB). We enrolled 100 adult patients undergoing elective cardiac surgery requiring CPB and who were in sinus rhythm at the time of surgery. Blood samples were obtained for measurement of plasminogen activator inhibitor - 1 (PAI - 1) in the morning of the operation and immediately after separation from CPB and administration of protamine. Patients who developed postoperative AF (28 patients, 28%) were significantly older (P=0.04), had history of hypertension (P = 0.035), performed graft to right coronary artery (P < 0.001), performed greater number of grafts (P=0.014), subjected to longer time of cardiopulmonary bypass (CPB) (P = 0.032), subjected to postoperative adminstration of epinephrine and dobutamine (P = 0.005), had lower postoperative ejection fraction (P = 0.028), had postoperative myocardial ischemia (P<0.001), had higher serum level of preoperative PAI - 1 (P = 0.0005), higher serum level of postoperative PAI - 1 (P < 0.0001), had larger left atrial diameter > 4 cm (P < 0.0001), had longer length of ICU stay (P = 0.04), and needed postoperative mechanical ventillation P = 0.0026 Issued also as CD Atrial fibrillation Inflammation Plasminogen activator inhibitor Mohamed Ahmed Elbadawy , Supervisor Mohamed Fawzy Abdelaleem , Supervisor Suzy Fawzy Michael , Supervisor http://172.23.153.220/th.pdf Nazla Revisor Samia Cataloger ddc TH 55480 55480 ddc 0 CUCL cl210 2024-02-11 Cai01.11.09.M.Sc.2015.Is.P 01010110068233000 2023-09-22 00:00:00 TH ddc 0 CUCL cl2u8 2024-02-11 Cai01.11.09.M.Sc.2015.Is.P 01020110068233000 2023-09-22 00:00:00 68233.CD CD