02328cam a2200265 a 4500003000900000005001700009008004100026040002800067041000800095100003000103245021600133246020600349260004900555300004300604502010300647520105900750530002201809653001701831653001501848653003901863700004501902700003701947700004501984856003302029EG-GiCUC20250223031443.0160319s2015    ua dh  f m    000 0 eng d  aEG-GiCUCbengcEG-GiCUC0 aeng0 aAmira Ramzy Ibrahim Okail10aEvaluation of vasular changes in morphea patients : bA dermoscopy guided immunohistochemical study / cAmira Ramzy Ibrahim Okail ; Supervised Manal A. W. Bosseila , Safinaz Salah Eldin Sayed , Marwah Adly Saleh15aتقييم نمط الأوعية الدموية فى مريض تصلب الجلد المحدد : bدراسة بواسطة الديرموسكوب و الكيمياء النسيجية المناعية  aCairo : bAmira Ramzy Ibrahim Okail , c2015  a97 P. : bcharts , facsimiles ; c25cm  aThesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Dermatology and Venerology  aMorphea is a rare autoimmune, inflammatory and fibrosing skin disorder that leads to sclerosis of the dermis and subcutaneous tissue. The underlying pathogenesis of the disease remains unknown, but is likely initiated by vascular injury that terminates in increased collagen production and decreased collagen destruction. Evaluation of vascular changes in morphea patients by dermoscopy and immunohistochemistry. Twenty patients who fulfilled the clinical and histological findings of morphea were included in this study. Patients were subjected to clinical examination, scoring of morphea lesions as well as dermoscopic examination using Dermlite II Hybrid. Two biopsies were taken from each patient: one from the morphea lesion and the second from the non-lesional skin. Paraffin sections were stained by vascular endothelial growth factor (VEGF) to identify blood vessels. Dermoscopic evaluation showed that morphea lesions exhibited a characteristic dermoscopic pattern showing the linear blood vessels with areas of shiny and hypopigmented fibrosis   aIssued also as CD 4aAngiogenesis 4aDermoscopy 4aVascular endothelial growth factor0 aManal Abdelwahad Bosseila , eSupervisor0 aMarwah Adly Saleh , eSupervisor0 aSafinaz Salah Eldin Sayed , eSupervisor  uhttp://172.23.153.220/th.pdf