02532cam a2200349 a 4500 EG-GiCUC 20250223031443.0 160319s2015 ua dh f m 000 0 eng d EG-GiCUC eng EG-GiCUC eng Deposite M.Sc Cai01.11.10.M.Sc.2015.Am.E Amira Ramzy Ibrahim Okail Evaluation of vasular changes in morphea patients : A dermoscopy guided immunohistochemical study / Amira Ramzy Ibrahim Okail ; Supervised Manal A. W. Bosseila , Safinaz Salah Eldin Sayed , Marwah Adly Saleh تقييم نمط الأوعية الدموية فى مريض تصلب الجلد المحدد : دراسة بواسطة الديرموسكوب و الكيمياء النسيجية المناعية Cairo : Amira Ramzy Ibrahim Okail , 2015 97 P. : charts , facsimiles ; 25cm Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Dermatology and Venerology Morphea is a rare autoimmune, inflammatory and fibrosing skin disorder that leads to sclerosis of the dermis and subcutaneous tissue. The underlying pathogenesis of the disease remains unknown, but is likely initiated by vascular injury that terminates in increased collagen production and decreased collagen destruction. Evaluation of vascular changes in morphea patients by dermoscopy and immunohistochemistry. Twenty patients who fulfilled the clinical and histological findings of morphea were included in this study. Patients were subjected to clinical examination, scoring of morphea lesions as well as dermoscopic examination using Dermlite II Hybrid. Two biopsies were taken from each patient: one from the morphea lesion and the second from the non-lesional skin. Paraffin sections were stained by vascular endothelial growth factor (VEGF) to identify blood vessels. Dermoscopic evaluation showed that morphea lesions exhibited a characteristic dermoscopic pattern showing the linear blood vessels with areas of shiny and hypopigmented fibrosis Issued also as CD Angiogenesis Dermoscopy Vascular endothelial growth factor Manal Abdelwahad Bosseila , Supervisor Marwah Adly Saleh , Supervisor Safinaz Salah Eldin Sayed , Supervisor http://172.23.153.220/th.pdf Nazla Revisor Samia Cataloger ddc TH 55616 55616 ddc 0 CUCL cl210 2024-02-11 Cai01.11.10.M.Sc.2015.Am.E 01010110068324000 2023-09-22 00:00:00 TH ddc 0 CUCL cl2u8 2024-02-11 Cai01.11.10.M.Sc.2015.Am.E 01020110068324000 2023-09-22 00:00:00 68324.CD CD