03259cam a2200349 a 4500 EG-GiCUC 20250223031518.0 160606s2015 ua dh f m 000 0 eng d EG-GiCUC eng EG-GiCUC eng Deposite M.Sc Cai01.11.09.M.Sc.2015.Mi.E Michael Soliman Megally Meshreky Elevated plasma levels of heparin binding protein and hyper lactatemia as predictor of outcome in intensive care unit patients with severe sepsis and septic shock / Michael Soliman Megally Meshreky ; Supervised Nashwa Abedalamir , Mohamed Ibrahim Eldesouky , Mohamed Hosni Abdallah ارتفاع نسبة البروتين المرتبط بالهيبارين و اللاكتات الشريانى فى الدم كمؤشر للناتج فى حالات الانتان الشديد بالدم و الصدمة الانتانية Cairo : Michael Soliman Megally Meshreky , 2015 160 P. : charts , facsimiles ; 25cm Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Critical Care Medicine Severe sepsis and septic shock represent one of the oldest and most pressing problems in medicine. With advances in intensive care, increased awareness, and dissemination of evidence based guidelines, clinicians have taken large strides in reducing the risk of imminent death associated with sepsis. Now days sepsis markers are currently more useful to rule out a diagnosis of sepsis than to actually identify sepsis, but potential new markers are being identified all the time. Heparin binding protein (HBP; also known as azurocidin and CAP37) is a multifunctional inflammatory mediator which is contained within the secretory and azurophilic granulae of human neutrophils and is secreted upon stimulation of the leukocytic membrane-bound Ý2-integrins. This protein is strongly involved in the pathophysiology of severe bacterial infections, and thus represents a potential diagnostic marker and a target for treatment. The present study was designed to evaluate the value of repeated measurements of heparin binding protein serum level in predicting the outcome in critically ill patients diagnosed with severe sepsis and septic shock compared to serum level of C- reactive protein and arterial lactate level. Our study consisted of 20 Egyptian non septic patients and they are considered the control group and randomized 40 Egyptian patients who were admitted to our ICU unit with picture of severe sepsis and septic shock and we have done repeated measurements of serum level of HBP, CRP and arterial lactate to the three groups on admission, on day 2 and day 4 comparing their values in prediction of outcome in severe sepsis and septic shock patients in ICU after 14 days follow up Issued also as CD ICU Septic shock Severe sepsis Mohamed Hosni Abdallah , Supervisor Mohamed Ibrahim Eldesouky , Supervisor Nashwa Abed Alamir , Supervisor http://172.23.153.220/th.pdf Nazla Revisor Samia Cataloger ddc TH 56805 56805 ddc 0 CUCL cl210 2024-02-11 Cai01.11.09.M.Sc.2015.Mi.E 01010110069268000 2023-09-22 00:00:00 TH ddc 0 CUCL cl2u8 2024-02-11 Cai01.11.09.M.Sc.2015.Mi.E 01020110069268000 2023-09-22 00:00:00 69268.CD CD