TY  - BOOK
AU  - Mohamed Tawfik Mohamed Nemr
AU  - Hanan Mohamed Refaat , 
AU  - Mohamed Mohsen Ismail , 
AU  - Mona Monir Kamel , 
TI  - Application of solid phase technique in the synthesis of certain heterocycles of expected pharmaceutical interest / 
PY  - 2016///
CY  - Cairo : 
PB  - Mohamed Tawfik Mohamed Nemr , 
KW  - Benzimidazoles
KW  - Quinoxalines
KW  - Solid phase synthesis
N1  - Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Organic Chemistry; Issued also as CD
N2  - This thesis comprises four chapters. The first chapter is an  introduction which includes the solid phase synthesis and biological  activity of benzimidazoles, quinoxalines and isoalloxazines. The second  chapter clarifies the objectives of the work and schemes designed for the  preparation of the target compounds. The third chapter deals with the  theoretical discussion of the experimental work, molecular docking and  results of cytotoxic activity. The fourth chapter includes the  experimental part of the thesis which contains the detailed procedures  used for the synthesis of the target compounds and intermediates, in  addition to their physical properties, their elemental analyses and spectral  data. Moreover, it includes the docking steps of all compounds. The in  vitro cytotoxic activity of the synthesized compounds on breast cancer  cell line (MCF-7), human hepatic cell line (HEPG2) and human  colorectal cell line (HCT116) compared with doxorubicin as a reference  anticancer agent is also included in this chapter
UR  - http://172.23.153.220/th.pdf
ER  -