Mohamed Mahmoud Rashad Elbadawy Badr <br/><br/>
Strong ion gap as a predictor of  outcome in septic patients /  
 فجوة الأيونات القوية كمؤشر للتنبؤ بنتاج مرضى التعفن الدموي  
Mohamed Mahmoud Rashad Elbadawy Badr ; Supervised Hassan Mohamed Khalid , Mahmoud Ali Elbadry , Abeer Mosbah Abdelhameed 
 - Cairo :   Mohamed Mahmoud Rashad Elbadawy Badr ,   2016 
 - 107 P. :   charts , facsimiles ;   25cm 
<br/><br/>Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Critical Care Medicine 
<br/><br/> Background: Acid base disturbances, especially metabolic acidosis are common in  septic patients. Physicochemical approach described by Stewart and modified by Figge  quantify precisely metabolic acidosis and gives insight into its main mechanisms, as well  as influence of unmeasured anion on metabolic acidosis. Aim. The aims of this study  were to determine the role of acid base variables obtained on admission to ICU and 24  hours later predicting outcome in septic patients; whether the strong ion differences (SID)  and strong ions gap (SIG) correlate with outcome from sepsis; comparison of predictive  value of acid base variables or SID/SIG variables versus other well-known severity  scores (like APATCHE II and SOFA scores). Results. Acute physiology and chronic health evaluation (APACHE II), SOFA  score, SIG, SIDe, anion gap (AG), corrected anion gap and SBE were statistically  significant predictors. Serum lactic acid had non-significant discriminating ability  between survivors and non survivors, but lactate clearance had better ability. ROC  analysis results showed that SIG followed by SIDe had the largest area below the curve  and were more sensitive and specific than other predictors.  
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<br/><br/><label>Subjects--Index Terms: </label>Metabolic acidosis  Strong ion difference  Strong ion gap