TY  - BOOK
AU  - Mugahed Mohammed Ahmed Algamrah
AU  - Ahmed Abdelbary Abdelrahman , 
AU  - Omneya Mohamed Abdelkader , 
TI  - Enhancement of solubility and bioavailability of glimepiride using nanotechnology / 
PY  - 2016///
CY  - Cairo : 
PB  - Mugahed Mohammed Ahmed Algamrah , 
KW  - Enhancement of solubility and bioavailability
KW  - Glimepiride
KW  - Nanotechnology
N1  - Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutics; Issued also as CD
N2  - Many of Poorly aqueous soluble drugs including antihypertensive agents, antidiabetic  agents and anti cancer agents require novel delivery technologies that will enhance  their GIT absorption, maximize their bioavailability and lead to efficient therapeutic  effect. Over the past two decades, there has been a steady rise in the number of  commercially available nanoparticle (NP), solid nanodispersion and solid lipid  nanoparticles (SLNs) therapeutics as novel delivery technologies intended to enhance  the GIT absorption, maximize the bioavailability and lead to efficient therapeutic  effect of poorly aqueous soluble drugs. Glimepiride is considered as new generation  of sulfonyl urea and administered orally. Its main draw back is its poor solubility.  Glimepiride, chemically described as 1-[[4-[2-(3-ethyl-4-methyl-2-oxo-3-pyrroline-1- carboxamide) ethyl] phenyl] sulphonyl] -3-(trans-4-methylcyclohexyil) urea, is water  insoluble oral antidiabetic drug from the sulfonylurea class, which is widely used in  the treatment of type 2 diabetes. Glimepiride was selected as drug candidate, as it is  not available in such dosage forms and thus, to enhance safety and efficacy of  Glimepiride, achieve better compliance, solve the problem of solubility, absorption  and bioavailability. To achieve these goals, the work in our thesis is divided into four  chapters
UR  - http://172.23.153.220/th.pdf
ER  -