03527cam a2200349 a 4500 EG-GiCUC 20250223031559.0 161019s2016 ua dh f m 000 0 eng d EG-GiCUC eng EG-GiCUC eng Deposite M.Sc Cai01.11.28.M.Sc.2016.At.B Athar Marwan Abdelaliem Ibrahim Bone metabolism and turnover markers in children with steroid-dependant \ frequently-relapsing and steroid- resistant nephrotic syndrome / Athar Marwan Abdelaliem Ibrahim ; Supervised Emad Emil Ghobrial , Hanan Abdelaziz Ahmed , Riham Elsayed Hanafy علامات التغير فى مكونات العظام لأطفال المصابين بالمتلازمة النفروزية المعتمدة على العلاج والغير مستجيبة للعلاج - بالكورتيزون Cairo : Athar Marwan Abdelaliem Ibrahim , 2016 122 P. : charts , facsimiles ; 25cm Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Pediatrics Background: Children with nephrotic syndrome may be at risk for metabolic bone disease because of biochemical derangement caused by renal disease as well as steroid therapy. Objectives: The aim of the work was to evaluate linear growth and bone turnover markers (Calcium, Phosphorus, Alkaline phosphatase and Osteocalcin) in nephrotic syndrome patients specially SDNS{u2215}FRNS and SRNS patients in comparison to a matched control group. Methods: The study is a cross sectional case-control study that included 30 patients with SDNS{u2215}FRNS and 30 SRNS patients aged 2-15 years matched with 28 healthy control children. Both patients and controls was subjected to clinical examination and we measured serum calcium, phosphorus, alkaline phosphatase and osteocalcin). Results: Height of both SDNS{u2215}FRNS and SRNS showed lower height for age percentile compared to control group (p=0.017 and 0.00 respectively). Also height of all NS patients were negatively correlated to duration of steroid, cyclophosphamide (CYP) and cyclosporine therapy (p= 0.05, p= 0.044 and 0.02 respectively).Lower serum calcium levels were (mean 8.9±0.8) mg/dL and significant lower calcium levels in all NS patients compared to the control group (P=0.0001). Higher ALP levels in both SDNS{u2215}FRNS and SRNS patients compared to control group but with statistical significance for only SRNS patients (p= 0.02). Higher Serum osteocalcin levels in both SDNS{u2215}FRNS and SRNS patients groups compared to the control group (P=0.02 and 0.01 respectively). We also found that osteocalcin levels were negatively correlated to serum calcium levels of our patients (p-value = 0.0001). Conclusion: Glucocorticoids therapy of NS patients especially on long term treatment in SDNS{u2215}FRNS and SRNS patients affects the height of patients and some markers of bone metabolism in the form of decrease serum Calcium level and increase serum alkaline phosphatase and osteocalcin level Issued also as CD Frequently-Relapsing and steroid Resistant nephrotic Syndrome Steroid-Dependant Emad Emil Ghobrial , Supervisor Hanan Abdelaziz Ahmed , Supervisor Riham Elsayed Hanafy , Supervisor http://172.23.153.220/th.pdf Nazla Revisor Samah Cataloger ddc TH 58191 58191 ddc 0 CUCL cl210 2024-02-11 Cai01.11.28.M.Sc.2016.At.B 01010110069961000 2023-09-22 00:00:00 TH ddc 0 CUCL cl2u8 2024-02-11 Cai01.11.28.M.Sc.2016.At.B 01020110069961000 2023-09-22 00:00:00 69961.CD CD