02547cam a2200349 a 4500 EG-GiCUC 20250223031614.0 161115s2016 ua f m 000 0 eng d EG-GiCUC eng EG-GiCUC eng Deposite M.Sc Cai01.11.28.M.Sc.2016.Ah.U Ahmed Sherif Abdelraouf Ahmed Urinary neutrophil gelatinase-associated lipocalin as a biomarker of disease activity in pediatric lupus nephritis / Ahmed Sherif Abdelraouf Ahmed ; Supervised Hala Salah Eldin Talaat , Miriam Magdy Aziz , Dalia Kadry Ismail ان - جى - ايه - ليبوكالين من الدلالات الحيوية فى البول لالتهاب الكلى فى مرض الذئبة الحمراء لدى الأطفال Cairo : Ahmed Sherif Abdelraouf Ahmed , 2016 105 P. ; 25cm Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Pediatrics More than 60% of children with systemic lupus erythematosus (SLE) develop lupus nephritis (LN). Neutrophil gelatinase associated lipocalin (NGAL) is a protein secreted by leukocytes during inflammation and is overexpressed in the kidneys following ischemic and nephrotoxic damage. To evaluate the role of urinary neutrophil gelatinase associated lipocalin-2 as a biomarker of renal involvement in SLE patients. Urinary levels of NGAL were assessed in 50 children with active SLE (25 with and 25 without LN) and compared to 25 matched controls. Children with SLE had elevated urinary NGAL (±295.8 ng / ml) as compared to controls (±124.4 ng / ml) (P < 0.001). Levels of urinary NGAL were higher in patients with LN (±822.8ng / ml) than those without LN (±295.8 ng / ml) (P < 0.001). In patients with LN, urinary levels of NGAL were correlated with the quantitative and qualitative measures of proteinuria (P < 0.001). Urinary NGAL was not significantly correlated with the histopathological classification by renal biopsy (P < 0.292). Urinary NGAL is a sensitive marker of proliferative nephritis in juvenile SLE Issued also as CD Lipocalin 2 Proliferative lupus nephritis Urinary NGAL Dalia Kadry Ismail , Supervisor Hala Salah Eldin Talaat , Supervisor Miriam Magdy Aziz , Supervisor http://172.23.153.220/th.pdf Nazla Revisor Samia Cataloger ddc TH 58620 58620 ddc 0 CUCL cl210 2024-02-11 Cai01.11.28.M.Sc.2016.Ah.U 01010110070244000 2023-09-22 00:00:00 TH ddc 0 CUCL cl2u8 2024-02-11 Cai01.11.28.M.Sc.2016.Ah.U 01020110070244000 2023-09-22 00:00:00 70244.CD CD