TY  - BOOK
AU  - Ahmad Lotfy Abdelmohsin 
AU  - Amira Elshennawy , 
AU  - Maha Hassan Abou Elew , 
AU  - Mostafa Elkhosht Mahmoud , 
TI  - Assessment of vestibular functions in patients with diabetes mellitus / 
PY  - 2015///
CY  - Cairo : 
PB  - Ahmad Lotfy Abdelmohsin , 
KW  - Diabetes Mellitus
KW  - SOT
KW  - VNG
N1  - Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of E.N.T; Issued also as CD
N2  - Background: Diabetes Mellitus (DM) and its complications are rapidly becoming  the world{u2019}s most significant cause of morbidity and mortality. Most of patients with DM complain of imbalance and/or dizziness. Objective: The aim of this  study was to study the changes of vestibular function in patients with DM and to  correlate the severity of diabetes to different vestibular findings. Methods: Forty  adult patients (mean age =49.12 ±9.03 years) with a confirmed diagnosis of DM underwent audio-vestibular assessment in the form of PTA, Immittancemetry,  bedside examination of dizziness, VNG, cVEMP and SOT. Results of these tests were compared with those of 20 age and sex matched control subjects selected  randomly. Both patients and controls were not known to have neither peripheral nor central vestibular disorders. The grade of neuropathy, level of HbA1c and  duration of DM were compared with vestibular tests results. Results: Bedside  examination was normal. Patients had high frequency SNHL, higher cVEMP threshold with longer P13 and N23 waves latency, less rations of SOT test, slower  saccadic eye movement, and less gain of both smooth pursuit and optokinetic eye  movements. Neuropathic patients had more delay in cVEMP waves and less SOM  ratio than non-neuropathics. Patients with longer DM duration showed prolonged latency of saccades. Severity of neuropathy was correlated with delay in cVEMP  waves and saccadic latency, while alternation of SOM ratio, saccadic velocity and  OPK gain were correlated to glycemic control. Conclusions: Diabetic patients  have a subclinical vestibular deficit that may appear with progression of DM complications. VSR is altered in diabetic patients, while the VOR is not  significantly affected. Alternation of vestibular functions is related more to  severity of neuropathy and glycemic control than duration of DM.
UR  - http://172.23.153.220/th.pdf
ER  -