Marwa Soliman Gaman Salama <br/><br/>
Synthesis and anti tumor evaluation of Heterocyclic compounds synthesized from Ý-diketone and active methylene derivatives /  
 تحضير و قياس مضادات الأورام لمركبات غير متجانسة الحلقة محضرة من مشتقات البيتا  ثنائى الكيتون و الميثيلين النشطة  
Marwa Soliman Gaman Salama ; Supervised  Rafat Milad Mohareb 
 - Cairo :   Marwa Soliman Gaman Salama ,   2016 
 - 120 P. ;   25cm 
<br/><br/>Thesis (M.Sc.) - Cairo University - Faculty of Science - Department of Organic Chemistry 
<br/><br/> In this work the reaction of O-phenylenediamine (1) with diethylmalonate (2) in an oil bath at 120 C gave ethyl 2- (1H-benzo [d] imidazol-2-yl) acetate (3). Compound 3 was used in many acyclic and heterocyclic reactions. The latter products underwent a series of heterocyclization reactions to yield pyrazole, thiophene, pyridine and coumarin derivatives. The antitumor evaluations of the newly synthesized products against three cancer cell lines were measured 
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<br/><br/><label>Subjects--Index Terms: </label>Benzimidazole compounds Heterocycles Synthesis