02754cam a2200349 a 4500 EG-GiCUC 20250223031648.0 170208s2016 ua dh f m 000 0 eng d EG-GiCUC eng EG-GiCUC eng Deposite M.Sc Cai01.11.28.M.Sc.2016.As.R Asmaa Salah eldin Ahmed Fathallah Risk factors of ketoacidosis at the diagnosis of diabetes mellitus / Asmaa Salah eldin Ahmed Fathallah ; Supervised Mona Mamdouh Hassan , Amany Ibrahim Mohamed , Noha Arafa Mohamed عوامل خطر الحماض الكيتونى عند تشخيص داء السكرى Cairo : Asmaa Salah eldin Ahmed Fathallah , 2016 121 P. : charts , facsimiles ; 25cm Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Pediatrics Introduction: Diabetes Mellitus (DM) is a metabolic disorder of glucose homeostasis and is one of the most common endocrine diseases in children worldwide. Diabetic ketoacidosis (DKA) is a common serious acute complication in children with DM. Its incidence in children at the onset of DM remains high, with approximately one-third presenting with mild DKA and one-sixth with moderate or severe DKA. Multiple factors affect the risk of developing DKA at the onset of DM in children. Aim of the study: to identify and analyze the risk factors associated with the development of ketoacidosis at the diagnosis of new cases with DM. Methods: Ninety nine children (53 DKA and 46 hyperglycemia) , age range from 1 month to 13 years, diagnosed with newly diagnosed diabetes, referred and managed at DEMPU in Children{u2019}s Hospital, Cairo University. Results: Classic symptoms (polyuria, polydipsia and weight loss) were the most common symptoms (93.8% & 92%) preceding the diagnosis; and diabetic ketoacidosis was present in 53.5%. Positive family history of diabetes was recorded in 54.5%, most of them with T2DM, but with no significant difference in the presentation. Delayed and missed diagnosis was recorded in 79.8% & 53.5% respectively, with significant difference affecting the presentation. Time lapse between diagnosis and start of insulin was found to be the most significant risk factor for developing DKA at diagnosis Issued also as CD Diabetes Diabetic ketoacidosis Risk factors Amany Ibrahim Mohamed , Supervisor Mona Mamdouh Hassan , Supervisor Noha Arafa Mohamed , Supervisor http://172.23.153.220/th.pdf Nazla Revisor Shaima Cataloger ddc TH 59750 59750 ddc 0 CUCL cl210 2024-02-11 Cai01.11.28.M.Sc.2016.As.R 01010110070838000 2023-09-22 00:00:00 TH ddc 0 CUCL cl2u8 2024-02-11 Cai01.11.28.M.Sc.2016.As.R 01020110070838000 2023-09-22 00:00:00 70838.CD CD