Asmaa Salah eldin Ahmed Fathallah creator Amany Ibrahim Mohamed Supervisor Mona Mamdouh Hassan Supervisor Noha Arafa Mohamed Supervisor text theses ua Cairo Asmaa Salah eldin Ahmed Fathallah 2016 monographic eng

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121 P. : charts , facsimiles ; 25cm Introduction: Diabetes Mellitus (DM) is a metabolic disorder of glucose homeostasis and is one of the most common endocrine diseases in children worldwide. Diabetic ketoacidosis (DKA) is a common serious acute complication in children with DM. Its incidence in children at the onset of DM remains high, with approximately one-third presenting with mild DKA and one-sixth with moderate or severe DKA. Multiple factors affect the risk of developing DKA at the onset of DM in children. Aim of the study: to identify and analyze the risk factors associated with the development of ketoacidosis at the diagnosis of new cases with DM. Methods: Ninety nine children (53 DKA and 46 hyperglycemia) , age range from 1 month to 13 years, diagnosed with newly diagnosed diabetes, referred and managed at DEMPU in Children{u2019}s Hospital, Cairo University. Results: Classic symptoms (polyuria, polydipsia and weight loss) were the most common symptoms (93.8% & 92%) preceding the diagnosis; and diabetic ketoacidosis was present in 53.5%. Positive family history of diabetes was recorded in 54.5%, most of them with T2DM, but with no significant difference in the presentation. Delayed and missed diagnosis was recorded in 79.8% & 53.5% respectively, with significant difference affecting the presentation. Time lapse between diagnosis and start of insulin was found to be the most significant risk factor for developing DKA at diagnosis specialized Asmaa Salah eldin Ahmed Fathallah ; Supervised Mona Mamdouh Hassan , Amany Ibrahim Mohamed , Noha Arafa Mohamed Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Pediatrics Issued also as CD Diabetes Diabetic ketoacidosis Risk factors http://172.23.153.220/th.pdf http://172.23.153.220/th.pdf EG-GiCUC 170208 20250223031648.0 eng