TY  - BOOK
AU  - Shahinaze Amry Aly Fouad
AU  - Emad B. Basalious , 
AU  - Mohamed Ahmed Elnabarawi , 
AU  - Saadia Ahmed Tayel , 
TI  - Pharmaceutical study on certain selective serotonin reuptake inhibitor / 
PY  - 2016///
CY  - Cairo : 
PB  - Shahinaze Amry Aly Fouad , 
KW  - Dapoxetine hydrochloride
KW  - Lyophilized matrices
KW  - Selective serotonin reuptake inhibitor
N1  - Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutics; Issued also as CD
N2  - Dapoxetine, as dapoxetine hydrochloride (D), is the first and only selective serotonin reuptake inhibitor licensed for the treatment of PE in men. However, oral D suffers from extensive first pass metabolism, resulting in poor bioavailability (42%). Therefore, transmucosal systems of D were designed in an attempt to increase its bioavailability. In chapter (I), a 2².3¹ full factorial design was employed to study the effect of different formulation variables. An optimized formulation was prepared and evaluated. It showed a rapid permeation compared to the drug suspension. In chapter (II), nanocarrier systems for transmucosal delivery of D were prepared. In chapter (III), Part (I) and (II) involved determination of the pharmacokinetics of D after sublingual and intranasal delivery from ISTM compared to the oral market product (priligy® 30 mg, tablets) and after the intranasal delivery of D from IDNP of the optimized formulation compared to the oral D-loaded nanocarrier formulation
UR  - http://172.23.153.220/th.pdf
ER  -