03284cam a2200349 a 4500 EG-GiCUC 20250223031702.0 170312s2016 ua o f m 000 0 eng d EG-GiCUC eng EG-GiCUC eng Deposite M.Sc Cai01.08.08.M.Sc.2016.Sa.C Sahar Atef Azmy Alshabasy Comparative study of different digoxin treatment regimens in Egyptian hospitals / Sahar Atef Azmy Alshabasy ; Supervised Samar Farid , Maggie Abbassi , Mohamed Selim درا{uئإآ٤}{uئإإء} {uئإؤئ}{uئإإ٤}{uئإؤ٨}{uئإ٨إ}ر{uئإإ٨}{uئإ٩٤} أ{uئإإ٨}ظ{uئإإ٤}{uئإإء} {uئإأآ}{uئإئأ}{uئإء٠}{uئإئ٤}{uئإ٩٤} {uئإإ٤}{uئإء٨}{uئإ٩٨}{uئإإ٠}{uئإؤ٤}{uئإ٩٤} {uئإؤئ}{uئإإ٠}د{uئإئ٤}{uئإء٠}و{uئإؤآ}{uئإآ٤}{uئإئ٤}ن فى ا{uئإؤئ}{uئإإ٤}{uئإآ٤}{uئإ٩٨}{uئإآ٨}{uئإؤ٤}{uئإئ٤}{uئإ٨إ}ت ا{uئإؤئ}{uئإإ٤}{uئإآأ}ر{uئإئ٤}{uئإ٩٤} Cairo : Sahar Atef Azmy Alshabasy , 2016 80 P. : photographs ; 25cm Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutics Digoxin is a cardiac glycoside prescribed in heart failure and atrial fibrillation. It exerts positive inotropic, neurohormonal and electrophysiological actions on the heart. Because of inter and intra-patient variability, narrow therapeutic index, and risk of toxicity, digoxin doses are calculated based on the patient weight, renal status, indications and drug interactions. In Egypt most cardiologists give digoxin holiday (the drug is off for one or two days a week) for both atrial fibrillation and heart failure to avoid possible drug accumulation and toxicity. It is not clear if these interrupted digoxin regimens really offer safer alternative over the continuous dosing regimens without compromising the effectiveness and patient quality of life. It is anticipated that plasma digoxin levels may fall below the therapeutic range during the holiday which may affect patient clinical status. To evaluate and compare the digoxin serum concentration and patient{u2019}s quality of life in the continuous versus interrupted digoxin dosing regimens. Patients were randomized to receive one of four regimens: regimen 1: one tablet (0.25mg) daily except Friday (N=17); regimen 2: one tablet (0.25mg) daily except Thursday and Friday (N=17); regimen 3: half tablet (0.125mg) daily (N=17); and regimen 4: a tailored dose was calculated based on patient{u2019}s renal function and given daily (N=23). After reaching steady state in the two holiday regimens, two plasma samples were collected (preholiday and post holiday trough concentrations); in the other two groups one trough plasma sample was collected Issued also as CD Atrial fibrillation Digoxin Interrupted regimens Maggie Abbassi , Supervisor Mohamed Selim , Supervisor Samar Farid , Supervisor http://172.23.153.220/th.pdf Nazla Revisor Samia Cataloger ddc TH 60231 60231 ddc 0 CUCL cl210 2024-02-11 Cai01.08.08.M.Sc.2016.Sa.C 01010110071281000 2023-09-22 00:00:00 TH ddc 0 CUCL cl2u8 2024-02-11 Cai01.08.08.M.Sc.2016.Sa.C 01020110071281000 2023-09-22 00:00:00 71281.CD CD